Bioengineering Hearts: Simple yet Complex

Heart rate : a simple yet complex concept -

The architecture of the sinus node, the atrioventricular conduction axis, and the internodal atrial myocardium R. H. Anderson and S. Y. Ho Multicentric origin of the atrial depolarization wave: the pacemaker complex. Relation to dynamics of atrial conduction, P-wave changes and heart rate control – J. P. Boineau and others Voltage-clamp investigations of membrane currents underlying pace-maker ...

A Case Report of Neonatal Pediculosis: A Simple Challenge, yet Complex

Background: Neonatal pediculosis is a problem the magnitude of which has not been estimated; however, it is regarded as a diagnostic challenge and becomes one of the management challenges for which there are very few managementoptions in terms of age, gestation, and the potential effects of drug toxicity.Case report: Here, we report a case of preterm who developed pediculosis capitis in t...

Dscam and DSCAM: complex genes in simple animals, complex animals yet simple genes.

Cadherins and the immunoglobulin (Ig) proteins give rise to a multitude of surface receptors, which function as diverse cell adhesion molecules (CAMs) or signal-transducing receptors. These functions are often interdependent, and rely on a high degree of specificity in homophilic binding as well as heterophilic interactions. The Drosophila receptor Dscam is an exceptional example of homophilic ...

A Simple yet Enduring Standard

In this issue of Circulation, Pardaens et al 1 examine the prognostic value of cardiopulmonary exercise testing in ambulatory patients with heart failure who are screened for cardiac transplantation. The investigators failed to demonstrate any significant advantage of ventilatory data over peak oxygen uptake (V̇O2). Over the past 10 years, several investigators have attempted to refine the use o...

polycystic ovary syndrome: an apparently simple yet challenging diagnosis